Christa E Flück Selected Research

Virilism (Virilization)

1/2021	Approach to the Virilizing Girl at Puberty.
1/2020	Inhibition of placental CYP19A1 activity remains as a valid hypothesis for 46,XX virilization in P450 oxidoreductase deficiency.
1/2017	Androgen production in pediatric adrenocortical tumors may occur via both the classic and/or the alternative backdoor pathway.
1/2016	Non-Virilizing Congenital Adrenal Hyperplasia in a Female Patient with a Novel HSD3B2 Mutation.
11/2015	Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature.
6/2014	Characterization of a novel CYP19A1 (aromatase) R192H mutation causing virilization of a 46,XX newborn, undervirilization of the 46,XY brother, but no virilization of the mother during pregnancies.
1/2013	Acute encephalopathy with unilateral cortical-subcortical lesions in two unrelated kindreds treated with glucocorticoids prenatally for congenital adrenal hyperplasia due to 21-hydroxylase deficiency: established facts and novel insight.
1/2011	Clinical and biochemical consequences of p450 oxidoreductase deficiency.
1/2008	P450 oxidoreductase deficiency - a new form of congenital adrenal hyperplasia.

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Christa E Flück Research Topics

Disease

17	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 12/2022 - 07/2006
10	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2020 - 08/2006
10	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2020 - 08/2006
10	Antley-Bixler Syndrome Phenotype 09/2017 - 03/2004
9	Virilism (Virilization) 01/2021 - 01/2008
8	Neoplasms (Cancer) 01/2021 - 01/2007
7	Starvation 01/2017 - 08/2010
6	46,XY Disorder of Sex Development (Male Pseudohermaphroditism) 11/2020 - 08/2011
6	Disorders of Sex Development (Intersexuality) 08/2020 - 05/2005
4	Lipoid congenital adrenal hyperplasia 01/2020 - 09/2005
4	Type II Isolated Growth Hormone Deficiency 01/2017 - 02/2010
3	Obesity 06/2022 - 01/2014
3	Type 2 Diabetes Mellitus (MODY) 01/2020 - 06/2005
3	Addison Disease (Addison's Disease) 01/2018 - 02/2014
3	Hypoglycemia (Reactive Hypoglycemia) 01/2011 - 06/2003
3	Craniosynostoses (Craniosynostosis) 01/2011 - 12/2005
2	Weight Loss (Weight Reduction) 06/2022 - 01/2020
2	Prostatic Neoplasms (Prostate Cancer) 04/2018 - 01/2017
2	Hyperpigmentation 01/2018 - 09/2002
2	Insulin Resistance 01/2017 - 03/2007
2	Hyperandrogenism 01/2017 - 03/2007
2	Cortisone reductase deficiency 11/2015 - 01/2014
2	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 01/2014 - 01/2013
2	Turner Syndrome (Turner's Syndrome) 07/2013 - 01/2012
2	Hyperplasia 01/2011 - 09/2005
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2010 - 06/2003
1	Weight Gain 06/2022
1	Hyperphagia (Overeating) 06/2022
1	Infertility (Sterility) 01/2022
1	Cystic Fibrosis (Mucoviscidosis) 01/2022
1	Acne Vulgaris 01/2021
1	Ovarian Torsion 04/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020
1	Meningioma (Meningiomas) 01/2019
1	And Genital Anomalies Adrenal Hypoplasia Congenita Metaphyseal Dysplasia Intrauterine Growth Retardation 09/2017
1	Ichthyosis (Xeroderma) 09/2017
1	Nephrotic Syndrome (Syndrome, Nephrotic) 09/2017
1	Adenoma (Adenomas) 01/2017
1	Carcinoma (Carcinomatosis) 01/2017
1	Rickets (Rachitis) 01/2016

Drug/Important Bio-Agent (IBA)

20	SteroidsIBA 01/2020 - 09/2005
18	AndrogensIBA 01/2021 - 03/2007
16	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 03/2004
14	EnzymesIBA 04/2018 - 03/2004
7	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2022 - 09/2002
6	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 04/2018 - 08/2006
6	Proteins (Proteins, Gene)FDA Link 01/2017 - 06/2010
6	3 beta-hydroxysteroid dehydrogenase type IIIBA 01/2016 - 08/2010
5	Hormones (Hormone)IBA 01/2021 - 06/2010
5	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2020 - 01/2011
5	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2020 - 03/2004
5	GlucocorticoidsIBA 01/2018 - 12/2007
4	Insulin (Novolin)FDA Link 01/2020 - 06/2005
4	Growth Hormone (Somatotropin)IBA 01/2019 - 06/2010
4	Pharmaceutical PreparationsIBA 04/2018 - 11/2004
3	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 09/2012
3	steroidogenic acute regulatory proteinIBA 01/2020 - 09/2005
3	Dihydrotestosterone (Androstanolone)IBA 01/2017 - 01/2008
3	MineralocorticoidsIBA 01/2016 - 09/2002
3	Insulin-Like Growth Factor I (IGF-1)IBA 12/2015 - 02/2010
3	Transcription Factors (Transcription Factor)IBA 01/2014 - 06/2005
3	Mixed Function Oxygenases (Monooxygenases)IBA 09/2012 - 08/2006
3	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 08/2006 - 05/2005
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 06/2005
2	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2022 - 11/2020
2	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 08/2020 - 08/2006
2	SaltsIBA 08/2020 - 07/2006
2	Aromatase deficiencyIBA 04/2020 - 06/2014
2	ElectrolytesIBA 01/2018 - 01/2011
2	Small Interfering RNA (siRNA)IBA 01/2017 - 01/2013
2	Estrogens (Estrogen)FDA Link 01/2017 - 01/2012
2	Vitamin D FDA LinkGeneric 01/2016 - 01/2010
2	Aromatase (CYP19)IBA 06/2014 - 11/2007
2	Estriol (Epiestriol)IBA 01/2011 - 01/2008
1	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 06/2022
1	Leptin ReceptorsIBA 06/2022
1	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 06/2022
1	setmelanotideIBA 06/2022
1	SubtilisinIBA 06/2022
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 06/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022
1	ivacaftor drug combination tezacaftorIBA 01/2022
1	elexacaftorIBA 01/2022
1	C 73IBA 01/2020
1	lopinavir-ritonavir drug combination (Kaletra)FDA Link 01/2019
1	Emtricitabine (Emtriva)FDA Link 01/2019
1	Tenofovir (Viread)FDA Link 01/2019
1	efavirenz (Sustiva)FDA Link 01/2019
1	Zidovudine (Retrovir)FDA LinkGeneric 01/2019
1	17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)IBA 01/2019
1	abirateroneIBA 04/2018
1	sphingosine 1-phosphate lyase (aldolase)IBA 09/2017
1	Histone Deacetylase InhibitorsIBA 01/2017
1	Antisense OligonucleotidesIBA 01/2017
1	ResveratrolIBA 01/2017
1	Biocompatible Materials (Biomaterials)IBA 02/2016

Therapy/Procedure

6	Therapeutics 04/2018 - 06/2005
2	Castration 01/2018 - 01/2017
1	Radiotherapy 01/2019
1	Injections 01/2017